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Yes, you can use a multi-effects pedal with an amp. In fact, it’s a common setup for many guitarists. The multi-effects pedal is connected in front of the amp, meaning it processes the sound before it reaches the amplifier. This way, you can use various effects like distortion, chorus, delay, reverb, and many more to shape your tone. Remember to adjust the levels of the pedal and the amp to avoid clipping or unwanted noise.